This paper aims to explore opportunities and modalities regarding corporate social responsibility of port logistics, in order to improve attractiveness and competitiveness of sea supply chains, almost paradoxically also in the perspective of increasing the traffics managed by global logistic players. In particular, beyond the traditional determinants of sea-ports’ efficiency, the study identifies the integration of processes among the different agents involved in the maritime supply chain as the keystone to increase the levels of efficacy, responsibility, and competitiveness. Important contributions for the integration is played firstly by the digitalization of seaport-related activities, but also by the evolution of sea-terminals towards a ‘social supply chain management’ approach, as a consequence of the implementation of corporate social responsibility practices in single nodes. A case study has been conducted on the Port of Venice, which has been compared with three important sea-terminals of Southern Italy: Naples, Gioia Tauro, and Bari.